Global Microbiome Manufacturing Market Size, Share, and COVID-19 Impact Analysis, Russia-Ukraine War Impact, Tariff Analysis, By Product Type (Probiotics, live biotherapeutics, Postbiotics, Prebiotics, Microbiome-targeted Therapeutics, and Others), By Manufacturing Process (Fermentation, Downstream Processing, Formulation & Packaging, and Quality Control & Testing), and By Region (North America, Europe, Asia-Pacific, Latin America, Middle East, and Africa), Analysis and Forecast 2025 - 2035

Microbiome Manufacturing Market Summary, Size & Emerging Trends

According to Spherical Insights, The Global Microbiome Manufacturing Market Size is Expected to grow from USD 26.2 Billion in 2024 to USD 146.5 Billion by 2035, at a CAGR of 16.94% during the forecast period 2025-2035. The increasing development in the microbiome sector and expanding GMP-compliant manufacturing capabilities are the key growth drivers for the global microbiome manufacturing market.

Key Market Insights

• North America is expected to account for the largest share in the Microbiome Manufacturing market during the forecast period.
• In terms of product type, the probiotics segment is projected to lead the microbiome manufacturing market in terms of product type throughout the forecast period
• In terms of manufacturing process, the fermentation segment captured the largest portion of the market throughout the forecast period
• In terms of end user, the pharmaceutical & biotechnology companies segment lead the market with a maximum share during the forecast period

Global Market Forecast and Revenue Outlook

• 2024 Market Size: USD 26.2 Billion
• 2035 Projected Market Size: USD 146.5 Billion
• CAGR (2025-2035): 16.94%
• North America: Largest market in 2024
• Asia Pacific: Fastest growing market

Microbiome Manufacturing Market

The microbiome manufacturing market is the industry encompassing the development and production of therapies and products that are derived from beneficial microorganisms for health and agriculture. An increasing need for effective medicine, drugs, and cancer therapies is escalating the growth of microbiome manufacturing. Further, with a growing demand for novel microbiome therapeutics, increasing technological advancements streamlining the manufacturing process. The growth of probiotics and advanced microbiome-based therapeutics, with increased demand for personalized healthcare contributing to promoting the microbiome manufacturing market.

Microbiome Manufacturing Market Trends

• Partnerships and collaborations promoting microbiome therapeutics contract manufacturing
• Advancement in the manufacturing, including integration of QbD principles and digital technologies like AI and IoT
• Personalized medicine and the growth of live biotherapeutic products, such as fecal microbiota transplantation, and chronic conditions.

Microbiome Manufacturing Market Dynamics

Driving Factors: The increasing pipeline of microbiome-based therapies is driving growth in the microbiome manufacturing market

The preference towards outsourcing manufacturing-related operations, along with the increasing collaborations among pharmaceutical companies, academic institutions, and research organizations, is contributing to escalating market growth. The use of microbiome therapeutics for diseases like digestive disorders, dermatological disorders, and oncological disorders, with emphasis on balancing microorganisms in the human body for various health benefits, is anticipated to drive the market demand.

Restrain Factors: The Microbiome Manufacturing market faces challenges due to the strict regulatory requirements and increased product price

The strict and lengthy regulatory process enhances the product's overall costs. Further, the increased cost of product development and production costs is restricting its adoption, thereby challenging the market growth of microbiome manufacturing.

Opportunity: An expanding biotechnology research activity is creating new opportunities in the microbiome manufacturing market

Expanding biotechnology research, including the advancements in genomics, gene editing, and synthetic biology, enables personalized microbiome-based therapies. Thus, investment in accelerating the development and commercialization of innovative microbiome-based treatments for conditions ranging from metabolic and immune disorders to infectious diseases is providing market growth opportunities.

Challenges: In the Microbiome Manufacturing market, the lack of standardized manufacturing processes and technologies, and a need for significant investment are challenging the market

The high investment required for specialized infrastructure and expertise in manufacturing is challenging the market. Further, the lack of standardized manufacturing processes and technologies affects product quality and yield, thereby impacting market growth.

Global Microbiome Manufacturing Market Ecosystem Analysis

The Global Microbiome Manufacturing Market ecosystem includes raw material suppliers, specialized manufacturers, technology providers, end users, and other supporting entities. Key technologies involve gene editing tools like next-generation sequencing and CRISPR-Cas9. Market growth is driven by an increasing pipeline of microbiome-based therapies, while stringent regulatory requirements and a lack of standardized protocols remain challenges. Opportunities lie in emerging markets and expanding biotechnology research activity.

Global Microbiome Manufacturing Market, By Product Type

The probiotics segment led the microbiome manufacturing market, generating a major market share. This dominance can be attributed to the growing health awareness and its therapeutic application. Probiotic manufacturing involves probiotic fermentation, nitrogen freezing, and freeze drying.

The live biotherapeutics segment in the microbiome manufacturing market is expected to grow at the fastest CAGR over the forecast period, driven by the growing significance of live biotherapeutic products for treating various diseases like inflammatory bowel syndrome, cancer, and neurological disorders.  

Global Microbiome Manufacturing Market, By Manufacturing Process

The fermentation segment held the largest portion in the microbiome manufacturing market, due to the growing need for natural and sustainable ingredients with the increasing popularity of fermented foods and beverages. Controlled bioreactors are used for cultivating and sustaining high-density cultures of target strains within the regulatory requirements.

The formulation & packaging segment in the microbiome manufacturing market is projected to register the fastest CAGR, driven by an increasing focus on stability, shelf life, and route-sensitive delivery of live products.

North America is expected to account for the largest share of the microbiome manufacturing market during the forecast period, driven by the presence of biotech companies pioneering live microbial therapeutics. An increasing collaboration with contract manufacturing organizations that offer technical expertise across different scales of operations is propelling the market growth.

The United States is experiencing steady growth in the microbiome manufacturing market, fueled by advances in sequencing technology and bioinformatics tools. Further, the development of innovative microbiome-based products, from probiotics to fecal microbiota transplantation therapies, is anticipated to propel market demand.

Asia Pacific is expected to grow at the fastest CAGR in the microbiome manufacturing market during the forecast period. This rapid growth is driven by increasing R&D investment and high production capacity by the governments and institutions. Further, an increasing demand for personalized health information and wellness solutions contributes to promoting the market growth of microbiome manufacturing.

India is rapidly expanding in the microbiome manufacturing market, due to strategic alliances of multinational sponsors and talent development. The growth in proactive research on human gut microbiota in the country is responsible for the market demand for microbiome manufacturing.

Competitive Analysis:

The report offers the appropriate analysis of the key organizations/companies involved within the microbiome manufacturing market, along with a comparative evaluation primarily based on their type of offering, business overviews, geographic presence, enterprise strategies, segment market share, and SWOT analysis. The report also provides an elaborative analysis focusing on the current news and developments of the companies, which includes product development, innovations, joint ventures, partnerships, mergers & acquisitions, strategic alliances, and others. This allows for the evaluation of the overall competition within the market.

WORLDWIDE TOP KEY PLAYERS IN THE MICROBIOME MANUFACTURING MARKET INCLUDE

• Seres Therapeutics
• Ferring Pharmaceuticals
• Vedanta Biosciences
• Finch Therapeutics
• Rebiotix (a Ferring Company)
• BiomX
• 4D Pharma
• Synlogic
• Enterome
• Second Genome
• Microbiotica
• BioGaia
• Prokarium
• ActoBio Therapeutics
• AOBiome
• Others

Key Target Audience

• Market Players
• Investors
• End-users
• Government Authorities 
• Consulting And Research Firm
• Venture capitalists
• Value-Added Resellers (VARs)

Product Launches in Microbiome Manufacturing

• In February 2025, MicrobioTx, a young research-based gut microbiome company, launched a new range of probiotics designed for addressing various wellness needs. The flagship probiotics line features formulations such as DigesTx, MoodTx, GlucoTx, and LeanTx.
• In February 2025, MGI Tech Co. Ltd., a company committed to building core tools and technologies, launched the latest Microbiome Metabarcoding Sequencing Package (“MMSP”), specifically designed to support scientists in microbiome research.
• In January 2025, Biohm Technologies, a specialist in microbiome research, ingredients, and products, announced the launch of a Longevity Gut Report functionality within its gut microbiome test kits.
• In June 2024, MicrobioTx, a Bengaluru-based gut health startup, announced the launch of India's first Hyper-Personalised Probiotic on World Microbiome Day.

Market Segment

This study forecasts revenue at global, regional, and country levels from 2020 to 2035. Spherical Insights has segmented the microbiome manufacturing market based on the below-mentioned segments: 

Global Microbiome Manufacturing Market, By Product Type

• Probiotics
• Live biotherapeutics
• Postbiotics
• Prebiotics
• Microbiome-targeted Therapeutics
• Others

Global Microbiome Manufacturing Market, By Manufacturing Process

• Fermentation
• Downstream Processing
• Formulation & Packaging
• Quality Control & Testing

Global Microbiome Manufacturing Market, By Regional Analysis

• North America
  • US
  • Canada
  • Mexico
• Europe
  • Germany
  • UK
  • France
  • Italy
  • Spain
  • Russia
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Australia
  • Rest of Asia Pacific
• South America
  • Brazil
  • Argentina
  • Rest of South America
• Middle East & Africa
  • UAE
  • Saudi Arabia
  • Qatar
  • South Africa
  • Rest of the Middle East & Africa