Global Enzymatic DNA Synthesis Market Size, Share, and COVID-19 Impact Analysis, Russia-Ukraine War Impact, Tariff Analysis, By Service (Oligonucleotide Synthesis and Gene Synthesis), By Application (Synthetic Biology, Genetic Engineering, Vaccine Development, and Others), and By Region (North America, Europe, Asia-Pacific, Latin America, Middle East, and Africa), Analysis and Forecast 2025 - 2035.

Global Enzymatic DNA Synthesis Market Insights Forecasts To 2035

• By Service, the oligonucleotide synthesis segment held the dominant position in the market and accounted for the leading revenue share.
• By Application, the synthetic biology segment led the market, holding the largest revenue share.
• North America dominated the global enzymatic DNA synthesis market with the largest revenue share.
• Asia Pacific is expected to grow the fastest during the forecast period.

The Global Enzymatic DNA Synthesis Market Size was Worth around USD 282.6 Million in 2024 and is predicted to Grow to around USD 3752.4 Million by 2035 with a compound annual growth rate (CAGR) of 26.5% from 2025 to 2035. Increased investments in biopharmaceuticals, growing demand for synthetic biology, advancements in gene editing, and the creation of scalable, affordable DNA synthesis technologies for sophisticated therapeutic and diagnostic applications present significant opportunities in the enzymatic DNA synthesis market.   

Market Overview

The global industry devoted to the creation, manufacturing, and marketing of DNA sequences through the use of enzyme-based technologies, as opposed to conventional chemical synthesis techniques, is known as the "enzymatic DNA synthesis market." A variety of uses in synthetic biology, genetic engineering, diagnostics, and drug discovery are supported by this novel method, which makes it possible to synthesize oligonucleotides and genes more quickly, accurately, and scalable.

The enzymatic DNA synthesis market includes a wide range of participants, such as academic institutions, pharmaceutical businesses, biotechnology companies, and contract research organizations. For Instance, in May 2025, Regeneron Pharmaceuticals, Inc. and Telesis Bio Inc., a leading supplier of DNA and mRNA synthesis solutions to speed therapeutic discovery with quick and adaptable on-site automated foundries, announced a new license agreement for the use of Telesis Bio's ground-breaking Gibson SOLATM platform at the company's R&D core facilities.

Growing need for precision medicine, more synthetic biology research, and more funding for genetic research and biotechnology are all expected to propel the enzymatic DNA synthesis market's expansion due to technological developments. The market for enzymatic DNA synthesis is being driven further by the growing biopharmaceutical industry, which is concentrating on genetic research and novel medicine development.  

Report Coverage

this research report categorizes the enzymatic DNA synthesis market based on various segments and regions, forecasts revenue growth, and analyzes trends in each submarket. The report analyses the key growth drivers, opportunities, and challenges influencing the enzymatic DNA synthesis market. Recent market developments and competitive strategies such as expansion, product launch, development, partnership, merger, and acquisition have been included to draw the competitive landscape in the market. The report strategically identifies and profiles the key market players and analyses their core competencies in each sub-segment of the enzymatic DNA synthesis market.  

Market Trends

• EDS is enabling breakthroughs in gene therapy, CRISPR editing, vaccine development, and personalized medicine, fueling market expansion.
• Enzymatic methods are cleaner and safer than traditional phosphoramidite synthesis, reducing hazardous waste and aligning with green biotech initiatives.
• Advances in enzymes (like TdT), AI-driven sequence optimization, and microfluidics are improving synthesis efficiency, length, and accuracy.

Driving Factors

Technology developments, the growing need for genetic research, the need for DNA-based diagnostics, the expansion of synthetic biology, and government financing and investments are some of the primary factors driving the enzymatic DNA synthesis market. The industry of enzymatic DNA synthesis is expanding quickly due to factors such as growing investment in biopharmaceutical research, the need for precision medicine, and genomics breakthroughs. The need for early diagnosis of genetic defects is becoming more widely recognized due to the increasing prevalence of genetic illnesses worldwide, which is driving the enzymatic DNA synthesis market.   

Restraining Factors

The market for enzymatic DNA synthesis is restricted by proven chemical synthesis techniques, which provide scalable, affordable, and reliable infrastructure. Additionally, wider acceptance across industrial and clinical applications is hampered by low throughput, high production costs, and technological immaturity.

Market Segmentation

The enzymatic DNA synthesis market share is classified into service and application.

• The oligonucleotide synthesis segment dominated the market in 2024 and is projected to grow at a substantial CAGR during the forecast period.

Based on the service, the enzymatic DNA synthesis market is divided into oligonucleotide synthesis and gene synthesis. Among these, the oligonucleotide synthesis segment dominated the market in 2024 and is projected to grow at a substantial CAGR during the forecast period. The growing need for accurate personalized oligonucleotides synthesis in both clinical and research contexts, as well as developments in synthesis methods that increase productivity and lower prices, are also expected to fuel the expansion.

The gene synthesis segment is expected to witness the fastest CAGR in the global enzymatic DNA synthesis market during the forecast period. The need for specialized genetic solutions and the increased focus on genetic research are driving the gene synthesis segment growth.

• The synthetic biology segment accounted for a dominant market share in 2024 and is anticipated to grow at a significant CAGR during the forecast period.

Based on the application, the enzymatic DNA synthesis market is divided into synthetic biology, genetic engineering, vaccine development, and others. Among these, the synthetic biology segment accounted for a dominant market share in 2024 and is anticipated to grow at a significant CAGR during the forecast period. The rapid developments and growing uses of synthetic biology in a variety of industries, such as medical development, agriculture, and environmental solutions, are responsible for the segment.  

The vaccine development segment is expected to witness a significant CAGR in the global enzymatic DNA synthesis market during the forecast period. The vaccine development segment is driven by the growing opportunities for DNA vaccines, which use modified DNA to elicit an immune response against bacteria, viruses, parasites, and cancer.  

Regional Segment Analysis of the Enzymatic DNA Synthesis Market

• North America (U.S., Canada, Mexico) 
• Europe (Germany, France, U.K., Italy, Spain, Rest of Europe)
• Asia-Pacific (China, Japan, India, Rest of APAC)
• South America (Brazil and the Rest of South America) 
• The Middle East and Africa (UAE, South Africa, Rest of MEA)

North America is anticipated to hold the largest share of the enzymatic DNA synthesis market over the predicted timeframe.

North America is anticipated to hold the largest share of the enzymatic DNA synthesis market over the predicted timeframe. North America is due to its substantial presence of important market participants, high levels of biotechnology investment, and expanding research infrastructure. Furthermore, the market's expansion has been fueled by the significant emphasis on innovation and development in genetic research, as well as significant support from the public and commercial sectors. The US accounted for the largest share of the enzymatic DNA synthesis market in 2024. The United States is propelled by a sophisticated biotechnology infrastructure, substantial research funding, and growing demand for high-throughput gene synthesis, synthetic biology, and precision medicine technologies.

Asia Pacific is expected to grow at a rapid CAGR in the Enzymatic DNA Synthesis market during the forecast period. The market is expanding due to a number of factors, including the region's growing research activities, growing investments in genomics and customized medicine, rapid biotechnology breakthroughs, and the expansion of healthcare infrastructure. China dominated the share of the Asia Pacific enzymatic DNA synthesis market in 2024. The market for enzymatic DNA synthesis is expected to grow as a result of the emergence of CROs and the outsourcing of drug discovery and development tasks by biotech and pharmaceutical companies.

Competitive Analysis:

The report offers the appropriate analysis of the key organizations/companies involved within the enzymatic DNA synthesis market, along with a comparative evaluation primarily based on their type of offering, business overviews, geographic presence, enterprise strategies, segment market share, and SWOT analysis. The report also provides an elaborative analysis focusing on the current news and developments of the companies, which includes product development, innovations, joint ventures, partnerships, mergers & acquisitions, strategic alliances, and others. This allows for the evaluation of the overall competition within the market.

List of Key Companies

• Evonetix
• DNA Script
• Touchlight
• Camena Bio
• Kern Systems
• Telesis Bio Inc.
• Molecular Assemblies
• GenScript Biotech Corp.
• Ansa Biotechnologies, Inc.
• Twist Bioscience Corporation
• Others

Key Target Audience

• Market Players
• Investors
• End-users
• Government Authorities 
• Consulting And Research Firm
• Venture capitalists
• Value-Added Resellers (VARs) 

Recent Development

• In May 2025, the dependable DNA synthesis partner Ansa Biotechnologies, Inc. announced the start of its 50 kb DNA synthesis early access program, which will enable clients to obtain incredibly lengthy and intricate DNA sequences in less than four weeks. Applications such as synthetic genomics, metabolic engineering, agricultural research, and next-generation cell and gene treatments all depend on DNA products of this length.

Market Segment

This study forecasts revenue at global, regional, and country levels from 2020 to 2035. Spherical Insights has segmented the enzymatic DNA synthesis market based on the below-mentioned segments: 

Global Enzymatic DNA Synthesis Market, By Service

• Oligonucleotide Synthesis
• Gene Synthesis

Global Enzymatic DNA Synthesis Market, By Application

• Synthetic Biology
• Genetic Engineering
• Vaccine Development
• Others

Global Enzymatic DNA Synthesis Market, By Regional Analysis

• North America
  • US
  • Canada
  • Mexico
• Europe
  • Germany
  • UK
  • France
  • Italy
  • Spain
  • Russia
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Australia
  • Rest of Asia Pacific
• South America
  • Brazil
  • Argentina
  • Rest of South America
• Middle East & Africa
  • UAE
  • Saudi Arabia
  • Qatar
  • South Africa
  • Rest of the Middle East & Africa