Global DNA-encoded Library market Size, Share, and COVID-19 Impact Analysis, By Therapeutic Area (Oncology, Infectious Diseases, Cardiovascular Diseases, Neurological Diseases, Autoimmune Diseases, Metabolic Diseases, and Others), By Application (Hit Generation / Identification, Hit to Lead, Hit Validation / Optimization, and Others), and By Region (North America, Europe, Asia-Pacific, Latin America, Middle East, and Africa), Analysis and Forecast 2025 - 2035

Global DNA-encoded Library market Insights Forecasts to 2035

• The Global DNA-encoded Library market Size Was Estimated at USD 754.8 Million in 2024
• The Market Size is Expected to Grow at a CAGR of around 13.35% from 2025 to 2035
• The Worldwide DNA-encoded Library market Size is Expected to Reach USD 2995.4 Million by 2035
• Asia Pacific is Expected to Grow the fastest during the forecast period.

The Global DNA-encoded Library Market Size was Worth around USD 754.8 Million in 2024 and is predicted to Grow to around USD 2995.4 Million by 2035 with a compound annual growth rate (CAGR) of 13.35% from 2025 and 2035. Growing investments in biotechnology, improvements in combinatorial chemistry, and growing demand for novel medicinal products drive market expansion and influence the direction of pharmaceutical innovation and precision medicine.   

Market Overview

The technologies that allow the synthesis and screening of large molecular libraries tagged with distinct DNA sequences are the main focus of the DNA-encoded library market. These libraries facilitate the quick identification of possible medicinal molecules, speeding up the drug discovery process. DNA-encoded library technology saves time and money in pharmaceutical development by improving hit detection, lead optimization, and target validation. Drug development has been revolutionized by DNA-encoded libraries, which offer a wide variety of molecules that can be investigated for possible medications. One of the main factors driving the market's strong expansion for DNA-encoded libraries is the growing range of applications across many therapeutic domains.  

In addition to encouraging partnerships between biotech and pharmaceutical companies, the market expansion draws investments, which propels the growth of the DNA-encoded library market as a whole. The growing need for effective drug discovery, high-throughput screening, affordable hit identification, and developments in DNA tagging technologies are some of the major factors driving the DNA-encoded library market.  

Report Coverage

This research report categorizes the DNA-encoded library market based on various segments and regions, forecasts revenue growth, and analyzes trends in each submarket. The report analyses the key growth drivers, opportunities, and challenges influencing the DNA-encoded library market. Recent market developments and competitive strategies such as expansion, type launch, development, partnership, merger, and acquisition have been included to draw the competitive landscape in the market. The report strategically identifies and profiles the key market players and analyses their core competencies in each sub-segment of the DNA-encoded library market.

Driving Factors

The expansion is driven by the growing need for creative drug discovery solutions. Companies in the biotechnology and pharmaceutical industries are always looking for more economical and effective ways to find possible medication candidates. The market for DNA-encoded library is anticipated to be driven by two business models: charging a fee-for-service for research utilizing their libraries and out-licensing proprietary library platforms to interested customers.

The market for DNA-encoded library is expected to increase rapidly in the near and far future due to improvements in drug discovery technology and the growing focus on precision medicine. The market for DNA-encoded library is expected to grow steadily as drug discovery paradigms continue to advance.     

Restraining Factors

The market for DNA-encoded library is restricted by issues including high prices, technological complexity, a narrow range of targets, regulatory barriers, intellectual property issues, and integration difficulty with current drug development frameworks.   

Market Segmentation

The DNA-encoded library market share is classified into therapeutic area and application.

• The oncology segment dominated the market in 2024 and is projected to grow at a substantial CAGR during the forecast period.

Based on the therapeutic area, the DNA-encoded library market is divided into oncology, infectious diseases, cardiovascular diseases, neurological diseases, autoimmune diseases, metabolic diseases, and others. Among these, the oncology segment dominated the market in 2024 and is projected to grow at a substantial CAGR during the forecast period. The strong need for specific cancer treatments is the main driver of the oncology industry. Potential small-molecule inhibitors for carcinogenic targets have been quickly discovered due to DNA-encoded library technology.     

• The hit generation/identification segment accounted for the largest share in 2024 and is anticipated to grow at a significant CAGR during the forecast period.

Based on the application, the DNA-encoded library market is divided into hit generation/identification, hit to lead, hit validation/optimization, and others. Among these, the hit generation/identification segment accounted for the largest share in 2024 and is anticipated to grow at a significant CAGR during the forecast period. The increasing demand for effective lead discovery solutions is the reason for the hit generation/identification segment. Large chemical library screening has become more affordable and scalable thanks to DNA-encoded library technology.   

Regional Segment Analysis of the DNA-encoded Library Market

• North America (U.S., Canada, Mexico) 
• Europe (Germany, France, U.K., Italy, Spain, Rest of Europe)
• Asia-Pacific (China, Japan, India, Rest of APAC)
• South America (Brazil and the Rest of South America) 
• The Middle East and Africa (UAE, South Africa, Rest of MEA)

North America is anticipated to hold the largest share of the DNA-encoded library market over the predicted timeframe.

North America is anticipated to hold the largest share of the DNA-encoded library market over the predicted timeframe. The supremacy of North America is the result of a strong ecosystem that includes active R&D programs, a flourishing pharmaceutical industry, and a never-ending hunt for novel drug discovery techniques. The growth of the DNA-encoded library market is actively supported by important players in the biotechnology and pharmaceutical industries, many of whom have their headquarters in North America. Furthermore, the region has access to a strong network of research institutes and state-of-the-art infrastructure, which supports ongoing developments in DNA-encoded library technologies.    

Asia Pacific is expected to grow at a rapid CAGR in the DNA-encoded library market during the forecast period. Asia Pacific is propelled by rising pharmaceutical research expenditures. DNA-encoded library technologies are being more widely used as emerging nations improve their biotech capabilities. New treatments must be developed due to the huge patient population. Partnerships with global pharmaceutical firms introduce cutting-edge technology to the region. The growth of DNA-encoded library services provided by Contract Research Organizations (CROs) facilitates market expansion. Due to these factors, the market for DNA-encoded library is expanding quickly in the Asia Pacific region.

Europe is predicted to hold a significant share of the DNA-encoded library market throughout the estimated period. The DNA-encoded library sector is steadily expanding in Europe as a result of a strong focus on research and innovation. Many biotech and pharmaceutical businesses in the region are investing in cutting-edge drug discovery methods. The creation and use of DNA-encoded library platforms are improved by international cooperation. The discipline continues to progress due to a strong academic and research community.  

Competitive Analysis:

The report offers the appropriate analysis of the key organizations/companies involved within the DNA-encoded library market, along with a comparative evaluation primarily based on their type of offering, business overviews, geographic presence, enterprise strategies, segment market share, and SWOT analysis. The report also provides an elaborative analysis focusing on the current news and developments of the companies, which includes type development, innovations, joint ventures, partnerships, mergers & acquisitions, strategic alliances, and others. This allows for the evaluation of the overall competition within the market.

List of Key Companies

• Merck KGaA
• Life Chemicals
• HitGen
• ComInnex
• Novartis
• GenScript
• DyNAbind
• Pharmaron
• WuXi Biology
• Nurix Therapeutics
• BOC Sciences
• LGC Bioresearch Technologies
• SPT Labtech Ltd
• Charles River Laboratories
• Others

Key Target Audience

• Market Players
• Investors
• End-users
• Government Authorities 
• Consulting And Research Firm
• Venture capitalists
• Value-Added Resellers (VARs)

Recent Development

• In April 2024, Vipergen and Aurigene Pharmaceutical Services Ltd. formed a strategic alliance to provide comprehensive drug discovery services. Vipergen's DNA-Encoded Library technology was used in the partnership to screen over a million small-molecule compounds to improve hit recognition. Co-developing new DNA-encoded libraries with enhanced chemical variety and drug-likeness was another of their plans.

• In September 2023, WuXi AppTec announced the official launch of an automated DNA-encoded library screening tool called DNA-encoded libraryman. With the use of the device's sophisticated fluidics system and integrated protocols, users could do DNA-encoded library screenings in 1.5 to 2 hours with little assistance from humans. Researchers may now conduct screenings in their laboratories thanks to DNA-encoded Libraryman, which was created to democratize access to DNA-encoded libraries. 

Market Segment

This study forecasts revenue at global, regional, and country levels from 2020 to 2035. Spherical Insights has segmented the DNA-encoded library market based on the below-mentioned segments: 

Global DNA-encoded Library Market, By Therapeutic Area

• Oncology
• Infectious Diseases
• Cardiovascular Diseases
• Neurological Diseases
• Autoimmune Diseases
• Metabolic Diseases
• Others

Global DNA-encoded Library Market, By Application

• Hit Generation/Identification
• Hit to Lead
• Hit Validation/Optimization
• Others

Global DNA-encoded Library Market, By Regional Analysis

• North America
  • US
  • Canada
  • Mexico
• Europe
  • Germany
  • UK
  • France
  • Italy
  • Spain
  • Russia
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Australia
  • Rest of Asia Pacific
• South America
  • Brazil
  • Argentina
  • Rest of South America
• Middle East & Africa
  • UAE
  • Saudi Arabia
  • Qatar
  • South Africa
  • Rest of the Middle East & Africa