Global Bioactive Bone Grafts Market Size, Share, and COVID-19 Impact Analysis, By Product Type (Putty Based, Prefilled, and Others), By Application (Dental, Cranio-maxilofacial, Foot and Ankle, Joint Reconstruction, and Others), By Region (North America, Europe, Asia-Pacific, Latin America, Middle East, and Africa), Analysis and Forecast 2025 - 2035.

Global Bioactive Bone Grafts Market Insights Forecasts To 2035

• The Global Bioactive Bone Grafts Market Size Was Estimated at USD 5.60 Million in 2024
• The Market Size is Expected to Grow at a CAGR of around 3.44% from 2025 to 2035
• The Worldwide Bioactive Bone Grafts Market Size is Expected to Reach USD 8.12 Million by
• 2035
• Asia Pacific is expected to grow the fastest during the forecast period.

According to a research report published by Spherical Insights and Consulting, The Global Bioactive Bone Grafts Market Size was worth around USD 5.60 Million in 2024, Growing to 5.75 Million in 2025, and is predicted to grow to around USD 8.12 million by 2035 with a compound annual growth rate (CAGR) of 3.44% from 2025 to 2035.  One of the key opportunities is the increasing preference for minimally invasive surgeries. Minimally invasive procedures require smaller incisions, and patients typically have shorter recovery times compared to traditional surgeries.  

Global Bioactive Bone Grafts Market Forecast and Revenue Size

• 2024 Market Size: USD 5.60 Million
• 2025 Market Size: USD 5.75 Million
• 2035 Projected Market Size: USD 8.12 Million
• CAGR (2025-2035): 3.44%
• North America: Largest market in 2024
• Asia Pacific: Fastest growing market

Market Overview

The commercial sector devoted to the creation, manufacturing, marketing, and use of bioactive bone graft materials and replacements is known as the bioactive bone grafts market. The biological activity of these cutting-edge biomaterials, which include demineralized bone matrices, bioactive glasses, composites, and synthetic ceramics, promotes osteoconduction, osteoinduction, and osteogenesis, enabling improved bone integration and regeneration in clinical settings. The increasing focus on individualized and patient-specific care offers market participants yet another excellent opportunity to provide unique and customized bioactive bone grafts.

The bioactive bone graft market is growing due to an increase in the rate of bone disorders, advances in regenerative medicine, and the aging population and their prior awareness of bone health. A notable recent development is that SCTIMST, Trivandrum, launched two novel drug-eluting bone grafts, CASPRO and BONYX, on 24 January 2025. The launch event was led by Shri S. Kris Gopalakrishnan, Hon'ble President, to mark the launch of the distribution to assist with improved bone healing with infection control. The increasing number of surgical treatments for bone repair and reconstruction, as well as growing investments in the infrastructure supporting dentistry and orthopedic care, are also driving the bioactive bone grafts market.   

Key Market Insights

• North America is expected to account for the largest share in the bioactive bone grafts market during the forecast period.
• In terms of product types, the putty-based segment is projected to lead the bioactive bone grafts market throughout the forecast period
• In terms of application, the dental segment captured the largest portion of the market

Report Coverage

This research report categorizes the bioactive bone grafts market based on various segments and regions, forecasts revenue growth, and analyzes trends in each submarket. The report analyzes the key growth drivers, opportunities, and challenges influencing the bioactive bone grafts market. Recent market developments and competitive strategies, such as expansion, type launch, development, partnership, merger, and acquisition, have been included to draw the competitive landscape in the market. The report strategically identifies and profiles the key market players and analyzes their core competencies in each sub-segment of the bioactive bone grafts market.

Driving factors: Musculoskeletal disorders drive the bioactive bone grafts market.

An increasing incidence of musculoskeletal disorders, along with orthopedic procedures that intend to utilize bioactive bone grafts, will be a driving factor in the expansion of the bioactive bone grafts market. One major contributing factor to the bioactive bone graft market includes the rising incidence of orthopedic-related diseases, as well as bone-related diseases like osteoarthritis, osteoporosis, and broken bones. The increasing demand for bioactive material in combination with bioactive bone grafts will spur the development of a bioactive bone grafts market. Technological advancements in the field of bioengineering, as well as biomaterials, have created an ever-expanding market for bioactive bone grafts market.

Restraining Factor: High costs and safety concerns restrict the market.

The market for bioactive bone grafts is restricted by several important factors, such as high production and surgical costs that restrict access, especially in developing nations, strict regulatory approvals that delay product launches, ethical issues with the sourcing of allografts, and safety risks like infections and incomplete bone integration that prevent widespread adoption.

Market Segmentation 

The global bioactive bone graft market is divided into product type and application.

Global Bioactive Bone Grafts Market, By Product Type:

Why does the putty-based segment hold the largest revenue share in the global bioactive bone grafts market?

The putty-based segment led the bioactive bone grafts market, generating the largest revenue share. The putty-based material is praised for its moldability, ease of handling, and capacity to adapt to intricate problem areas during surgery. Growing physicians' desire for grafts that shorten operating times and improve patient outcomes has contributed to the segment's expansion. Additionally, putty-based grafts provide improved mixing with growth hormones or autologous materials, improving bone repair.      

The prefilled segment in the bioactive bone grafts market is expected to grow at the fastest CAGR over the forecast period. The prefilled segment is a robust expansion, estimated at approximately 7.6% or greater, stemming from its user-friendly design, precise application in orthopedic and dental surgeries, and superior integration for expedited bone regeneration, surpassing putty-based and other variants.

Global Bioactive Bone Grafts Market, By Application:

What is the main factor driving the growth of the dental application segment?

The dental segment held the largest market share in the bioactive bone grafts market. The growing incidence of tooth loss, periodontal disease, and dental implant procedures, all of which require the use of bone graft materials to promote effective outcomes, is the main factor propelling the dental application segment. Improvements in graft formulations that promote faster healing and enhance osseointegration in alveolar bone replacement have benefited the segment.    

The joint reconstruction segment in the bioactive bone grafts market is expected to grow at the fastest CAGR over the forecast period. Bioactive bone grafts are increasingly being used in joint reconstruction, including hip and knee replacement procedures. The necessity for joint reconstruction treatments is being driven by the rising prevalence of joint illnesses such rheumatoid arthritis and osteoarthritis.  

Regional Segment Analysis of the Global Bioactive Bone Grafts Market

• North America (U.S., Canada, Mexico) 
• Europe (Germany, France, U.K., Italy, Spain, Rest of Europe)
• Asia-Pacific (China, Japan, India, Rest of APAC)
• South America (Brazil and the Rest of South America) 
• The Middle East and Africa (UAE, South Africa, Rest of MEA)

North America Bioactive Bone Grafts Market Trends

What factors contribute to North America region holding the largest share, approximately 42%, of the global bioactive bone grafts market during the forecast period?

North America is dominance in the global bioactive bone grafts market, with an estimated 42% share during the forecast period. The growing use of cutting-edge medical technologies, the well-established healthcare system, and the high incidence of orthopedic disorders are the main factors propelling the market in this region. The presence of significant market players and the continuous R&D efforts are anticipated to further accelerate the market's expansion in North America.  

Why does the United States lead the North American bioactive bone grafts market?

A growing number of orthopedic surgeries, an aging population, and advancements in synthetic bioactive materials such as tricalcium phosphate and hydroxyapatite are driving the market for bioactive bone grafts in the United States. Regenerative medicine is also driving the market, as is the growing need for minimally invasive procedures.

What factors are contributing to the growth of the bioactive bone grafts market in Canada?

The market for bioactive bone grafts in Canada, which are essential for orthopedic and dental applications, is anticipated to grow significantly within the larger bone graft and substitute industry. An aging population, an increase in orthopedic problems, and advancements in synthetic bioactive materials that improve osteointegration and biocompatibility are all factors contributing to growth.

Asia Pacific Bioactive Bone Grafts Market Trends

How is the Asia Pacific region expected to capture approximately 19% of the bioactive bone grafts market by 2025 with the fastest growth rate? 

Asia Pacific is expected to capture approximately 19% of the bioactive bone grafts market by 2025 with the fastest growth rate due to several key factors. The APAC region is a result of the growing need for quality orthopedic care, the rise in orthopedic injuries, and the aging populations of nations like China and India. A growing aging population, rising healthcare costs, and more knowledge of cutting-edge medical treatments are the main drivers propelling the market expansion in this region.

Why is China expected to register the highest CAGR in the bioactive bone grafts market during the forecast period?

Growing orthopedic treatments, an aging population, and developments in synthetic bioactive materials like ceramics and bioactive glass that improve biocompatibility and regenerative efficacy are driving the growth of the China bioactive bone grafts market.

Why is the bioactive bone grafts market growing in India?

The market for bioactive bone grafts in India is expanding due to an aging population, an increase in orthopedic procedures, and developments in synthetic bioactive materials that improve biocompatibility and speed up recovery, like bioactive glass and ceramics.

Competitive Analysis:

The report offers the appropriate analysis of the key organizations/companies involved within the global bioactive bone grafts market, along with a comparative evaluation primarily based on their type of offering, business overviews, geographic presence, enterprise strategies, segment market share, and SWOT analysis. The report also provides an elaborate analysis focusing on the current news and developments of the companies, which includes type development, innovations, joint ventures, partnerships, mergers & acquisitions, strategic alliances, and others. This allows for the evaluation of the overall competition within the market.

Worldwide Top Key Players in The Bioactive Bone Grafts Market Include

• NuVasive Inc.
• Medtronic Plc
• Stryker Corporation
• Dentsply Sirona Inc.
• Smith & Nephew Plc
• Geistlich Pharma AG
• Orthofix Holdings Inc.
• Kuros Biosciences AG
• NovaBone Products LLC
• Baxter International Inc.
• RTI Surgical Holdings Inc.
• Wright Medical Group N.V.
• Botiss Biomaterials GmbH
• Zimmer Biomet Holdings Inc.
• Others

Key Target Audience

• Market Players
• Investors
• End-users
• Government Authorities 
• Consulting And Research Firm
• Venture capitalists
• Value-Added Resellers (VARs)

Recent development

• In June 2025, the U.S. Food and Drug Administration (FDA) announced the premarket approval (PMA) of PearlMatrixTM P-15 Peptide Enhanced Bone Graft as a Class III drug-device combination product for use in single-level transforaminal lumbar interbody fusion (TLIF) surgery in adult patients with degenerative disc disease (DDD). Cerapedics Inc. is a global, commercial-stage orthopedics company committed to redefining the path to bone repair.  

• In January 2025, Medtronic has announced a five-year agreement to distribute Kuros Biosciences’ MagnetOs bone graft in U.S. spine procedures, offering an alternative to autografts. This comes as Medtronic continues marketing its Infuse product, previously involved in legal settlements over safety concerns.

• In May 2024, Biogennix, LLC, a company based in Irvine, announced that it has been granted FDA 510(k) clearance for a new indication for its Agilon Moldable and Morpheus Moldable bone grafting products. The FDA has approved an intervertebral body fusion device for use with a bone void filler, and the new clearance permits the items to be used in the intervertebral disc space as an autograft extender.

• In October 2023, OsteoCove is a novel bioactive synthetic graft that Orthofix Medical Inc. announced has acquired 510(k) approval and is now fully available for purchase. OsteoCove had outstanding bone-forming properties for a range of orthopedic and spine treatments and came in putty and strip form.

• In September 2022, FIBERGRAFT Technology has launched a new line of porous synthetic bone graft substitutes, featuring FIBERGRAFT BG Morsels made from interlocking 45S5 bioactive glass fibers, offering versatile solutions across procedures and enhancing bone regeneration through advanced bioactive glass technology.

Market Segment

This study forecasts revenue at the global, regional, and country levels from 2020 to 2035. Spherical Insights has segmented the bioactive bone grafts market based on the following segments:

 Global Bioactive Bone Grafts Market, By Product Type,

• Putty based
• Prefilled
• Others

Global Bioactive Bone Grafts Market, By Application

• Dental
• Cranio-maxilofacial
• Foot and Ankle
• Joint Reconstruction
• Others

Global Bioactive Bone Grafts Market, By Regional Analysis

• North America
  • US
  • Canada
  • Mexico
• Europe
  • Germany
  • UK
  • France
  • Italy
  • Spain
  • Russia
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Australia
  • Rest of Asia Pacific
• South America
  • Brazil
  • Argentina
  • Rest of South America
• Middle East & Africa
  • UAE
  • Saudi Arabia
  • Qatar
  • South Africa
  • Rest of the Middle East & Africa