Global Antibody Purification Service Market Size, Share, and COVID-19 Impact Analysis, Russia-Ukraine War Impact, Tariff Analysis, By Type (Physiochemical Fractionation, Class-Specific Affinity, and Antigen-Specific Affinity), By Application (Monoclonal Antibodies and Polyclonal Antibodies), By Region (North America, Europe, Asia-Pacific, Latin America, Middle East, and Africa), Analysis and Forecast 2025 - 2035

Global Antibody Purification Service Market Insights Forecasts to 2035

• The Global Antibody Purification Service Market Size Was Estimated at USD 2.65 Billion in 2024
• The Market Size is Expected to Grow at a CAGR of around 7.19% from 2025 to 2035
• The Worldwide Antibody Purification Service Market Size is Expected to Reach USD 5.69 Billion by 2035
• Asia Pacific is Expected to grow the fastest during the forecast period.

According to a research report published by Spherical Insights and Consulting, the global antibody purification service market size was worth around USD 2.65 billion in 2024 and is predicted to grow to around USD 5.69 billion by 2035 with a compound annual growth rate (CAGR) of 7.19 % from 2025 to 2035. Various life science companies offer antibody purification services with tailored purification strategies based on the antibody’s source and application. It is anticipated that the increasing biopharmaceutical R&D activity, advancements in purification technologies, and surging need for high-quality antibodies will support market growth.

Global Antibody Purification Service Market Forecast and Revenue Outlook

• 2024 Market Size: USD 2.65 Billion
• 2035 Projected Market Size: USD 5.69 Billion
• CAGR (2025-2035): 7.19%
• North America: Largest market in 2024
• Asia Pacific: Fastest growing market

Market Overview

The antibody purification service market is an industry that encompasses the expertise and technology for isolating and enriching specific antibodies from biological sources, such as serum or cell cultures, to enhance their suitability for research, diagnostic, and therapeutic applications. Antibody purification is the process of isolating antibodies from complex mixtures through multi-step chromatography techniques, selected based on the antibodies' biological characteristics such as molecular charge, size, and hydrophobicity. Antibody purification involves the process of isolating polyclonal antibodies from serum or monoclonal antibodies from ascites or hybridoma cell culture supernatants to obtain high-purity, high-activity antibodies that meet specific application requirements. An optimized design based on the antibodies' biological characteristics and sources is used in the antibody purification process.

The global market share is anticipated to be supported by expanding R&D efforts by major industry participants, including ThermoFischer Scientific, Abcam, Bio-Rad Laboratories, and others, for developing new purification methods in order to enhance antibody efficiency and specificity. There are opportunities in the developing market due to the surging trend towards outsourcing purification services, with companies placing increased emphasis on core competencies. For instance, in January 2025, Boster Biological Technology revolutionized biotechnology research with an advanced multiplex ELISA service. Further, in January 2025, NanoImaging Services acquired Proteos, enhancing integrated protein sciences and structure-based discovery capabilities.

Key Market Insights

• North America is expected to account for the largest share in the Antibody Purification Service Market during the forecast period.
• In terms of type, the physiochemical fractionation segment is projected to lead the antibody purification service market throughout the forecast period
• In terms of applications, the monoclonal antibodies segment captured the largest portion of the market

Antibody Purification Service Market Trends

• Adoption of advanced technologies such as single-use systems and membrane chromatography
• Increasing emphasis on process optimization and automation
• Manufacturing sustainability and AI integration for process improvement & data analysis

Report Coverage

This research report categorizes the antibody purification service market based on various segments and regions, forecasts revenue growth, and analyzes trends in each submarket. The report analyzes the key growth drivers, opportunities, and challenges influencing the antibody purification service market. Recent market developments and competitive strategies, such as expansion, type launch, development, partnership, merger, and acquisition, have been included to draw the competitive landscape in the market. The report strategically identifies and profiles the key market players and analyzes their core competencies in each sub-segment of the antibody purification service market.

Driving factors

The expanding biopharmaceutical R&D driven by the investments in drug discovery and development of advanced therapeutic formats, including bispecific antibodies and antibody-drug conjugates (ADCs), is contributing to driving the antibody purification service market. Technological advancements in purification techniques, including high-performance liquid chromatography (HPLC), affinity chromatography, and other advanced techniques, for improved antibody purification are propelling market growth. Additionally, an increasing demand for high-quality antibodies for repeatable research, diagnostics, and therapeutics is anticipated to propel market demand.

Restraining Factor

One of the main factors restraining the antibody purification service market is the increased production cost and regulatory complexities. Further, the surging need for technical expertise and issues related to scaling up production are challenging the market growth.

Market Segmentation 

The global antibody purification service market is divided into type and applications.

Global Antibody Purification Service Market, By Type:

• The physiochemical fractionation segment dominated the market with the largest share in 2024 and is projected to grow at a substantial CAGR during the forecast period.   

Based on type, the global antibody purification service Market is segmented into physiochemical fractionation, class-specific affinity, and antigen-specific affinity. Among these, the physiochemical fractionation segment dominated the market with the largest share in 2024 and is projected to grow at a substantial CAGR during the forecast period. Physiochemical fractionation includes differential precipitation, size-exclusion, or solid-phase binding of immunoglobulins based on size, charge, or other shared chemical characteristics of antibodies. An increasing need for cost-effective, scalable purification methods, especially in the biopharma production, is driving the market in the physiochemical fractionation segment.

The antigen-specific affinity segment is anticipated to grow at a significant CAGR during the forecast period, due to the specificity and effectiveness of antigens for the affinity purification of targeted antibodies. Antigen-specific affinity purification involves the use of a target antigen for isolating specific antibodies from a complex sample.

Global Antibody Purification Service Market, By Application:

• The monoclonal antibodies segment accounted for the largest market share in 2024 and is anticipated to grow at a significant CAGR during the forecast period.

Based on application, the global antibody purification service market is segmented into monoclonal antibodies and polyclonal antibodies. Among these, the monoclonal antibodies segment accounted for the largest market share in 2024 and is anticipated to grow at a significant CAGR during the forecast period. Purification of monoclonal antibodies is essential for ensuring the safety and efficacy of mAb therapeutics. An increasing adoption of monoclonal antibodies for treating chronic conditions is anticipated to drive the market demand.

The polyclonal antibodies segment is anticipated to grow at a significant CAGR during the forecast period, owing to its widespread application in immunoassays, vaccine development, and biomarker discovery. Protein A/G purification is a method of choice for the purification of polyclonal antibodies from animal serum.

Regional Segment Analysis of the Global Antibody Purification Service Market

• North America (U.S., Canada, Mexico) 
• Europe (Germany, France, U.K., Italy, Spain, Rest of Europe)
• Asia-Pacific (China, Japan, India, Rest of APAC)
• South America (Brazil and the Rest of South America) 
• The Middle East and Africa (UAE, South Africa, Rest of MEA)

North America Antibody Purification Service Market Trends

North America is expected to hold the largest share of the global antibody purification service market over the forecast period.

The North American region's supremacy includes the increasing investment in biotechnology research, along with the presence of a well-established pharmaceutical market and personalized medicine. Further, the increased adoption of innovative technologies, along with an increasing need for therapeutic & diagnostic antibodies, is propelling the market for antibody purification.

U.S. Antibody Purification Service Market Trends

U.S. is anticipated to grow at a rapid rate in the antibody production market, driven by the presence of advanced biopharmaceutical infrastructure, increased demand for therapeutic & diagnostic antibodies. Further, increased chronic disease prevalence rates and expanding biologics and drug discovery sectors are contributing to the market growth.

Asia Pacific Antibody Purification Service Market Trends

Asia Pacific is expected to grow at a rapid CAGR in the antibody purification service market during the forecast period. In the Asia Pacific market, the healthcare research investments, growth in the biopharma industry, and increased use of antibody therapies are driving the antibody purification market. In addition, the increasing need for therapeutic and diagnostic antibodies across the region is propelling market demand.

China Antibody Purification Service Market Trends

China is witnessing rapid CAGR growth in the Asia Pacific market for antibody purification, due to the government support, strategic collaborations between biotech firms and leading universities. Further, the country’s increasing presence of contract research organizations (CROs) is supporting the antibody purification market.

Competitive Analysis:

The report offers the appropriate analysis of the key organizations/companies involved within the global antibody purification service market, along with a comparative evaluation primarily based on their type of offering, business overviews, geographic presence, enterprise strategies, segment market share, and SWOT analysis. The report also provides an elaborate analysis focusing on the current news and developments of the companies, which includes type development, innovations, joint ventures, partnerships, mergers & acquisitions, strategic alliances, and others. This allows for the evaluation of the overall competition within the market.

Worldwide Top Key Players In The Antibody Purification Service Market Include

• BioRad Laboratorie
• Agilent Technologies
• Hycult Biotech
• Merck KGaA
• Creative Biolabs
• GenScript
• Abcam
• HoffmannLa Roche
• Cytiva
• SigmaAldrich
• Genway Biotech
• Invitrogen
• Thermo Fisher Scientific
• FabUSA
• GE Healthcare
• Others  

Key Target Audience

• Market Players
• Investors
• End-users
• Government Authorities 
• Consulting And Research Firm
• Venture capitalists
• Value-Added Resellers (VARs)

Recent development

• In June 2025, Ecolab Life Science announced it had launched an innovative new resin to help achieve cost savings and optimise operations throughout the antibody manufacturing process.
• In April 2025, Cytiva, a global leader in life sciences, expanded its industry-leading MabSelect protein A resin portfolio with the launch of MabSelect SuRe 70 and MabSelect PrismA X resins for cost-effective and scalable mAb purification.
• In February 2021, FairJourney Biologics (FJB) and IONTAS, leaders in the discovery and optimization of antibodies, announced the launch of a new protein sciences division, Flow Eighteen38. The new business unit has been introduced to accelerate customer antibody research projects by delivering reagents, purified proteins, and characterization data on antibody panels and leads.

Market Segment

This study forecasts revenue at the global, regional, and country levels from 2020 to 2035. Spherical Insights has segmented the Antibody Purification Service Market based on the following segments:

 Global Antibody Purification Service Market, By Type

• Physiochemical Fractionation
• Class-Specific Affinity
• Antigen-Specific Affinity

Global Antibody Purification Service Market, By Application

• Monoclonal Antibodies
• Polyclonal Antibodies

Global Antibody Purification Service Market, By Regional Analysis

• North America
  • US
  • Canada
  • Mexico
• Europe
  • Germany
  • UK
  • France
  • Italy
  • Spain
  • Russia
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Australia
  • Rest of Asia Pacific
• South America
  • Brazil
  • Argentina
  • Rest of South America
• Middle East & Africa
  • UAE
  • Saudi Arabia
  • Qatar
  • South Africa
  • Rest of the Middle East & Africa