Global Monocyte Activation Test Market Size To Exceed USD 2363.40 Million by 2033: Forecast Analysis Report

RELEASE DATE: May 2025 Author: Spherical Insights
The Global Monocyte Activation Test Market Size is Expected to Grow from USD 528.40 Million in 2023 to USD 2363.40 Million by 2033, at a CAGR of 16.16% during the forecast period 2023-2033.

Table of Contents

Historical Data, Premium Insights, Market Dynamic, Analysis and Projection, By Product, Analysis and Projection, By Application, Analysis and Projection, By End-Use, Analysis and Projection, By Regional Analysis, Competitive Landscape, Company Profiles, Market Revenue, Sale & Price Analysis


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Global Monocyte Activation Test Market Size To Exceed USD 2363.40 Million by 2033

According to a research report published by Spherical Insights & Consulting, The Global Monocyte Activation Test Market Size is Expected to Grow from USD 528.40 Million in 2023 to USD 2363.40 Million by 2033, at a CAGR of 16.16% during the forecast period 2023-2033.               

 

Browse 210 market data Tables and 45 Figures spread through 190 Pages and in-depth TOC on the Global Monocyte Activation Test Market Size, Share, and COVID-19 Impact Analysis, By Source (Cell Line Based and Peripheral Blood Mononuclear Cells), By Application (Drug Development, Vaccine Development, Medical Devices, and Others), and By Region (North America, Europe, Asia Pacific, Latin America, Middle East, and Africa), Analysis and Forecast 2023 – 2033.                    
 

Monocyte activation test (MAT) market means the industry to develop, produce, and adopt in vitro pyrogen detecting assays based on measurement of monocyte activation and release of cytokines. MAT is a superior, consistent, non-animal, pyrogen alternative to rabbit-based tests, the Rabbit Pyrogen Test (RPT), and Limulus Amebocyte Lysate (LAL) test due to their sensitivity, compliance to ethics, and regulatory tolerability. Moreover, Monocyte Activation Test (MAT) Market growth is driven by increasing demand for animal-free pyrogen testing, growing pharmaceutical and biologics manufacturing, and strict regulatory guidelines with an edge for in vitro testing. Cell-based assay advancements, growing adoption in vaccine and drug safety testing, and ethical issues related to animal testing increase market growth. Technological advancements also improve MAT efficiency and accuracy. However, low awareness among the end-users, the high implementation cost of MAT, and the assay standardization complexity are factors that restrain the market growth. Regulatory differences between regions, along with the preference for historical pyrogen tests, are also challenges.

 

The cell line-based segment accounted for the largest share of the global monocyte activation test market in 2023 and is anticipated to grow at a significant CAGR during the forecast period.            

On the basis of source, the global monocyte activation test market is divided into cell line-based and peripheral blood mononuclear cells. Among these, the diagnosis biomarker segment accounted for the largest share of the global monocyte activation test market in 2023 and is anticipated to grow at a significant CAGR during the forecast period. This is because of their high reproducibility, consistency, and convenience over peripheral blood mononuclear cells (PBMCs). Donor variability elimination, cost-effectiveness, and growing regulatory acceptance also fuel their extensive use in pharmaceutical and biotechnology companies.

 

The drug development segment accounted for a substantial share of the global monocyte activation test market in 2023 and is anticipated to grow at a rapid pace during the projected period.

On the basis of the application, the global monocyte activation test market is divided into drug development, vaccine development, medical devices, and others. Among these, the drug development segment accounted for a substantial share of the global monocyte activation test market in 2023 and is anticipated to grow at a rapid pace during the projected period. This is because of the increased demand for pyrogen testing in drugs, strict regulatory standards, and growing drug approvals. The transition towards in vitro testing, progress in biologics, and the requirement for credible safety evaluations also fuel its market dominance.

 

North America is projected to hold the largest share of the global monocyte activation test market over the projected period.  

North America is projected to hold the largest share of the global monocyte activation test market over the projected period. This is because of established pharmaceutical and biotechnology sectors, strict regulatory frameworks supporting in vitro testing, and high usage of sophisticated testing technologies. The existence of major industry players and rising R&D expenditures also add to the region's dominance.

 

Asia Pacific is expected to grow at the fastest CAGR of the global monocyte activation test market during the projected period. This is attributable to growing pharmaceutical and biologics manufacturing, heightened regulatory attention to drug safety, and rising awareness of in vitro pyrogen testing. Developing healthcare infrastructure, government programs, and the presence of new biotech firms further propel market expansion in nations such as China, India, and Japan.

 

Company Profiling 

Major vendors in the global monocyte activation test market are Lonza Group, Thermo Fisher Scientific, Bio-Rad Laboratories, Seikagaku Corporation, Charles River Laboratories, Eurofins Scientific, Merck KGaA, Hyglos GmbH, MAT BioTech, Wako Chemicals USA., and Other.

 

Key Target Audience

  • Market Players
  • Investors
  • End-users
  • Government Authorities 
  • Consulting and Research Firm
  • Venture capitalists
  • Value-Added Resellers (VARs)

 

Recent Development

  • In October 2023, Lonza Group reported the introduction of two new rapid monocyte activation test (MAT) systems, the PyroCell MAT Human Serum (HS) Rapid System and the PyroCell MAT Rapid System, to simplify and streamline rabbit-free pyrogen testing.

 

Market Segment

This study forecasts revenue at global, regional, and country levels from 2023 to 2033. Spherical Insights has segmented the global monocyte activation test market based on the below-mentioned segments:

 

Global Monocyte Activation Test Market, By Source

  • Cell Line Based
  • Peripheral Blood Mononuclear Cells

 

Global Monocyte Activation Test Market, By Application

  • Drug Development
  • Vaccine Development
  • Medical Devices
  • Others

 

Global Monocyte Activation Test Market, By Regional

  • North America
    • US
    • Canada
    • Mexico
  • Europe
    • Germany
    • UK
    • France
    • Italy
    • Spain
    • Russia
    • Rest of Europe
  • Asia Pacific
    • China
    • Japan
    • India
    • South Korea
    • Australia
    • Rest of Asia Pacific
  • South America
    • Brazil
    • Argentina
    • Rest of South America
  • Middle East & Africa
    • UAE
    • Saudi Arabia
    • Qatar
    • South Africa
    • Rest of the Middle East & Africa

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