United States Nucleotide Market Size, Share, and COVID-19 Impact Analysis, By Product (Deoxy Nucleotides, Dideoxynucleotides, Nucleotides for RNA Synthesis (rNTP), and Labelled Nucleotides), By Technology (TaqMan Allelic Discrimination, Gene Chips & Microarrays, SNP by Pyrosequencing, and Others), and United States Nucleotide Market Insights, Industry Trend, Forecasts to 2035.

United States Nucleotide Market Insights Forecasts to 2035

• The US Nucleotide Market Size Was Estimated at USD 322.8 Million in 2024
• The Market Size is Expected to Grow at a CAGR of around 8.52% from 2025 to 2035
• The US Nucleotide Market Size is Expected to Reach USD 793.6 Million by 2035

According to a research report published by Spherical Insights & Consulting, the United States Nucleotide Market is anticipated to reach USD 793.6 million by 2035, growing at a CAGR of 8.52% from 2025 to 2035. The expansion of the United States nucleotide market is propelled by the expanding range of sectors using nucleotides, including medicines, food and beverage additives, animal feed additives, and diagnostic research.

Market Overview

Nucleotides refer to the building units of nucleic acids like DNA and RNA, are essential for the storage and transfer of genetic information in all living organisms. Nucleotides are a key commodity in genetic testing, and they are essential for accurate diagnosis, detection of mutations, and facilitating personalised treatment protocols. There will be an increase in the market for nucleotide-based flavour enhancers, as a result of heightened consumer awareness of the adverse effects of savoury food additives. There is a growing need for advanced diagnostic capability, as genetic diseases such as cancer, cardiovascular disease, and inherited disorders are becoming more prevalent. Furthermore, the introduction of nucleotides in technology is changing molecular diagnostics through next-generation sequencing and PCR, improving the market growth and extending its use in research and healthcare. The ability to quantify biological material in microgravity increases research in genetic mechanisms and variables.

The U.S. government has supported the nucleotide industry through a number of initiatives, especially in fields like genomic research, gene therapy, and RNA-based therapies. The Food and Drug Administration (FDA), the Advanced Research Projects Agency for Health, and the National Institutes of Health are the main organisations leading these initiatives.

Report Coverage

This research report categorizes the market for the United States nucleotide market based on various segments and regions and forecasts revenue growth and analyses trends in each submarket. The report analyses the key growth drivers, opportunities, and challenges influencing the United States nucleotide market. Recent market developments and competitive strategies such as expansion, product launch, development, partnership, merger, and acquisition have been included to draw the competitive landscape in the market. The report strategically identifies and profiles the key market players and analyses their core competencies in each sub-segment of the United States nucleotide market.

Driving Factors

The growth of the United States nucleotide market is boosted by the massive investment into developing or expanding new pharmaceutical facilities and a sizable investment into developing new drugs. The pharmaceutical sector is experiencing tremendous growth.  Nucleotides have a significant impact on the rapid growth and proliferation of immune and gastrointestinal tract cells. They have also been used successfully as dietary supplements to improve the immune system and disease resistance. As a result, the need for nucleotides within the pharmaceutical sector is also increasing in tandem. The market is now growing through increased funding and regulatory support for genetic research and biotechnology-driven initiatives.

Restraining Factors

The United States nucleotide market faces obstacles like the aquaculture uses relatively little nucleotides compared with human and animal diets. Public ignorance about the benefits of nucleotides has been a major deterrent to their inclusion in aquafeed. The knowledge gap surrounding the level of nucleotides that should be included in feed, with concerns about food safety.

Market Segmentation

The United States nucleotide market share is classified into product and technology.

• The deoxy nucleotides segment held the largest market share in 2024 and is expected to grow at a remarkable CAGR during the forecast period.

The United States nucleotide market is segmented by product into deoxy nucleotides, dideoxynucleotides, nucleotides for RNA synthesis (rNTP), and labelled nucleotides. Among these, the deoxy nucleotides segment held the largest market share in 2024 and is expected to grow at a remarkable CAGR during the forecast period. The segment is driven by their critical role in genetic research and DNA synthesis. Deoxy nucleotides are essential components of DNA and are useful in molecular diagnostics, gene sequencing, and PCR. Demand has been driven by applications in biotechnology and advances in genomics and personalised medicine.

• The taqman allelic discrimination segment held the highest revenue share in 2024 and is expected to grow at a significant CAGR during the forecast period.

Based on the technology, the United States nucleotide market is segmented into taqman allelic discrimination, gene chips & microarrays, SNP by pyrosequencing, and others. Among these, the taqman allelic discrimination segment held the highest revenue share in 2024 and is expected to grow at a significant CAGR during the forecast period. The segmental growth is propelled due to their extensive use in diagnostics, genetic research, and genotyping. Taqman assays entail the detection of allelic differences and genetic variation in a reliable manner using specific primers and probes. It is routinely used in pharmacogenomics, personalisation of medicine, and testing for disease susceptibility.

Competitive Analysis:

The report offers the appropriate analysis of the key organizations/companies involved within the United States nucleotide market, along with a comparative evaluation primarily based on their product offering, business overviews, geographic presence, enterprise strategies, segment market share, and SWOT analysis. The report also provides an elaborate analysis focusing on the current news and developments of the companies, which includes product development, innovations, joint ventures, partnerships, mergers & acquisitions, strategic alliances, and others. This allows for the evaluation of the overall competition within the market.

List of Key Companies

• Promega
• Agilent Technologies Inc
• Thermo Fisher Scientific Inc
• GenScript Biotech Corporation
• Twist Bioscience
• Azenta, Inc.
• LGC Biosearch Technologies
• ProteoGenix
• Bioneer Corporation
• Others

Recent Development

• In November 2024, PTC Therapeutics, Inc. announced the FDA's accelerated approval of its gene therapy for AADC deficiency. This milestone makes it the first-ever gene therapy in the U.S. to be directly administered to the brain for treatment.

Key Target Audience

• Market Players
• Investors
• End-users
• Government Authorities 
• Consulting and Research Firm
• Venture capitalists
• Value-Added Resellers (VARs)

Market Segment

This study forecasts revenue at the United States, regional, and country levels from 2020 to 2035. Spherical Insights has segmented the United States nucleotide market based on the following segments:

United States Nucleotide Market, By Product

• Deoxy Nucleotides
• Dideoxynucleotides
• Nucleotides for RNA Synthesis (rNTP)
• Labelled Nucleotides

United States Nucleotide Market, By Technology

• TaqMan Allelic Discrimination
• Gene Chips & Microarrays
• SNP by Pyrosequencing
• Others