United States gRNA Market Size, Share, and COVID-19 Impact Analysis, By Product & Services (Products and Custom gRNA Synthesis Services), By gRNA Type (Research-Use and GMP-grade), and United States GRNA Market Insights, Industry Trend, Forecasts to 2035

United States gRNA Market Size Insights Forecasts to 2035   

• The US gRNA Market Size Was Estimated at USD 276.8 Million in 2024
• The Market Size is Expected to Grow at a CAGR of around 17.81% from 2025 to 2035
• The US gRNA Market Size is Expected to Reach USD 1679.9 Million by 2035

According to a Research Report Published by Spherical Insights & Consulting, the United States GRNA Market Size is anticipated to reach USD 1679.9 Million by 2035, growing at a CAGR of 17.81% from 2025 to 2035. The expansion of the United States' gRNA market is propelled by its pivotal role in CRISPR-based genetic editing.

Market Overview

A guide RNA (gRNA), also known as sgRNA when it is present in single-molecule form, is the crucial address label used in CRISPR-Cas gene editing. gRNA is in high demand because of its necessary role in CRISPR genetic editing. gRNA is a necessary resource for precise gene editing because it has the capacity to target the CRISPR system to exact locations within a DNA sequence. Scientists and researchers utilize gRNA to target and modify genes in a systematic way, which has led to advancements in biotechnology, agricultural practices, and advances in medicine. Due to gRNAs' precision, effectiveness, and adaptability, numerous organisations will keep using them for a variety of purposes, including creating new farming methods, comprehending fundamental biological processes, and investigating possible new treatments for hereditary disease. gRNA will play an important role in genetic research as the race for specific genetic modification intensifies. One of the major market drivers in gRNAs is increasing research and development activity in proteomics and genomics. The goal of genomics research and development is to understand gene functions, discover and validate potential therapeutic targets. Researchers use gRNAs to alter relevant genes, evaluate the effects, and identify and validate meaningful targets. The need for gRNA technology is rising as a result of significant investments made by both public and private entities in proteomics and genomics research. The U.S. government, announced USD 1.7 billion in funding in April 2021 to promote and advance genome sequencing technologies.

Report Coverage

This research report categorizes the market for the United States gRNA market based on various segments and regions and forecasts revenue growth and analyses trends in each submarket. The report analyses the key growth drivers, opportunities, and challenges influencing the United States gRNA market. Recent market developments and competitive strategies such as expansion, product launch, development, partnership, merger, and acquisition have been included to draw the competitive landscape in the market. The report strategically identifies and profiles the key market players and analyses their core competencies in each sub-segment of the United States gRNA market.

Driving Factors

The growth of the United States gRNA market is boosted by the increased research and therapeutic uses of CRISPR-Cas9. gRNA, a synthetic RNA molecule, is a mechanism to deliver the Cas9 enzyme to the specific genomic sites for gene editing. The research lab's broad use of CRISPR to examine gene functions, causes of diseases, and possible treatment targets will help to drive the demand for custom gRNA synthesis. Also, the rapid advancement of CRISPR-based therapeutics into clinical trials for various genetic diseases will require the synthesis of high-quality gRNA for use in clinical settings. The expanding pipeline of therapeutics related to gRNA is an important driver in the gRNA market.

Restraining Factors

The United States gRNA market faces obstacles due to delivery methods and the consequences of off-target editing. While CRISPR offers unprecedented specificity and accuracy, off-target edits at sites other than the intended target sequence remain a significant concern because unintended edits may lead to undesired cellular changes or adverse events in therapeutic contexts.

Market Segmentation

The United States gRNA market share is classified into product & services and gRNA Type.

• The products segment held the largest market share in 2024 and is expected to grow at a remarkable CAGR during the forecast period.

The United States gRNA market is segmented by product & services into products and custom gRNA synthesis services. Among these, the products segment held the largest market share in 2024 and is expected to grow at a remarkable CAGR during the forecast period. The segment is driven by its great researcher acceptance, high precision, efficiency, specificity, and ease of use, which makes it possible for academic and biotech labs to conduct rapid, repeatable CRISPR studies.

• The research-use segment held the highest revenue share in 2024 and is expected to grow at a significant CAGR during the forecast period.

Based on the gRNA Type, the United States gRNA market is segmented into research-use and GMP-grade. Among these, the research-use segment held the highest revenue share in 2024 and is expected to grow at a significant CAGR during the forecast period. The segmental growth is propelled by research projects with various research centers that require research-grade gRNA. Due to increasing gRNA usage in clinical research, the market is expected to continue flourishing throughout the forecast period. The expanding use of CRISPR also drives the gRNA demand in the research use market, as CRISPR is one of the most widely used gene editing approaches

Competitive Analysis:

The report offers the appropriate analysis of the key organizations/companies involved within the United States gRNA market, along with a comparative evaluation primarily based on their product offering, business overviews, geographic presence, enterprise strategies, segment market share, and SWOT analysis. The report also provides an elaborate analysis focusing on the current news and developments of the companies, which includes product development, innovations, joint ventures, partnerships, mergers & acquisitions, strategic alliances, and others. This allows for the evaluation of the overall competition within the market.

List of Key Companies

• Synthego
• Azenta Life Sciences
• System Biosciences
• Agilent Technologies Inc
• Thermo Fisher Scientific Inc
• Synthego Corporation
• PacBio
• Intellia Therapeutics
• Beam Therapeutics
• Excision BioTherapeutics
• Others

Key Target Audience

• Market Players
• Investors
• End-users
• Government Authorities 
• Consulting and Research Firm
• Venture capitalists
• Value-Added Resellers (VARs)

Market Segment

This study forecasts revenue at the United States, regional, and country levels from 2020 to 2035. Spherical Insights has segmented the United States gRNA market based on the following segments:

United States GRNA Market, By Product & Services

• Products
• Custom gRNA Synthesis Services

United States GRNA Market, By gRNA Type

• Research-Use
• GMP-grade