United States Endoscopic Submucosal Dissection Market Size, Share, and COVID-19 Impact Analysis, By Product (Injection Agents, Gastroscopes & Colonoscopes, Graspers, Tissue Retractors, and Knives), By Indication (Colon Cancer, Oesophageal Cancer, and Stomach Cancer), By End-User (Outpatient Facilities and Hospitals), and US Endoscopic Submucosal Dissection Market Insights, Industry Trend, Forecasts to 2035

USA Endoscopic Submucosal Dissection Market Insights Forecasts to 2035

• The US Endoscopic Submucosal Dissection Market Size was Estimated at USD 125.84 Million in 2024
• The Market Size is Expected to Grow at a CAGR of around 3.95% from 2025 to 2035
• The USA Endoscopic Submucosal Dissection Market Size is Expected to reach USD 192.71 Million by 2035

According to a research report published by Spherical Insights & Consulting, the US Endoscopic Submucosal Dissection Market Size is anticipated to reach USD 192.71 Million by 2035, Growing at a CAGR of 3.95% from 2025 to 2035. The market growth is attributed to the increasing prevalence of gastrointestinal disorders and gastric cancer, sedentary lifestyles.

Market Overview

The market for endoscopic submucosal dissection (ESD) is a market in the USA that focuses on minimally invasive techniques for the early removal of tumors from the stomach, colon, and oesophagus. A minimally invasive therapeutic technique called endoscopic submucosal dissection (ESD) is used to remove large polyps or early, non-metastatic lesions from the gastrointestinal tract. Precancerous and malignant tissues are removed during the procedure using an endoscope, a flexible tube-like instrument equipped with a camera. En-bloc resection is more common with this technique than endoscopic mucosal resection, and it is tailored for larger tumors. For malignant tumors with intramucosal-to-superficial submucosal invasion, submucosal fibrotic lesions (less than 2 cm) that cannot be removed by endoscopic mucosal resection, situations where a snare is unlikely to allow for successful en-bloc resection, and the removal of large polyps, lesions without transanal access, and early colorectal cancer in patients avoiding major surgical resection, ESD is typically recommended. Trends like improved haemostatic methods, robot-assisted procedures, and real-time AI-driven lesion detection systems are driving the ESD market. Medical device manufacturers have a significant market opportunity as a result of the acceleration of ESD adoption brought about by investments in physician training programs and skill development initiatives.

Report Coverage

This research report categorizes the market for the US endoscopic submucosal dissection market based on various segments and regions and forecasts revenue growth and analyzes trends in each submarket. The report analyses the key growth drivers, opportunities, and challenges influencing the US endoscopic submucosal dissection market. Recent market developments and competitive strategies such as expansion, product launch, development, partnership, merger, and acquisition have been included to draw the competitive landscape in the market. The report strategically identifies and profiles the key market players and analyses their core competencies in each sub-segment of the US endoscopic submucosal dissection market.

Driving Factors

The rising prevalence of gastrointestinal disorders, improvements in endoscopic technology, an aging population, and the need for minimally invasive procedures are all predicted to contribute to the significant growth of the global endoscopic submucosal dissection (ESD) market. To improve patient outcomes, ESD is being used more and more for the early detection and treatment of gastrointestinal cancers, including colorectal, gastric, and oesophageal cancers. ESD is growing as a result of technological developments like sophisticated endotherapy tools and equipment. Accuracy and safety during ESD treatments are increased by high-definition imaging systems, upgraded electrosurgical blades, and specialized accessories. The availability of sophisticated endoscopic procedures and increased awareness of gastrointestinal disorders both support the growing use of ESD, which propels market expansion. Compared to traditional open surgery, the ESD technique has benefits like less trauma, scarring, quicker recovery and healing times, and better cosmetic outcomes.

Restraining Factors

The high overhead costs, complex training requirements, limited adoption in developing regions, regulatory challenges, and patient awareness and acceptance which may restrict the market growth.

Market Segmentation

The USA endoscopic submucosal dissection market share is classified into product, indication, and end-user.

• The knives segment held the largest share 30.89% in 2024 and is expected to grow at a significant CAGR during the forecast period.

The US endoscopic submucosal dissection market is segmented by product into injection agents, gastroscopes & colonoscopes, graspers, tissue retractors, and knives. Among these, the knives segment held the largest share 30.89% in 2024 and is expected to grow at a significant CAGR during the forecast period. This is attributed to the visualization of the visualization, precise cutting, controlled dissection, and effective haemostasis. They allow for accurate incision and submucosal dissection, reducing the risk of incomplete tumor removal. Some knives, like the Dual Knife, create sharp cuts with minimal thermal damage, preserving surrounding tissues. ESD knives are versatile, providing marking, mucosal incision, dissection, and haemostasis

• The stomach cancer segment accounted for the largest share in 2024 and is expected to grow at a significant CAGR during the forecast period.

The US endoscopic submucosal dissection market is segmented by indication into colon cancer, oesophageal cancer, and stomach cancer. Among these, the stomach cancer segment accounted for the largest share in 2024 and is expected to grow at a significant CAGR during the forecast period. This is owing to the increasing prevalence of stomach cancer, poor dietary habits, and alcohol consumption.

• The hospitals segment accounted for the largest share in 2024 and is expected to grow at a significant CAGR during the forecast period.

The US endoscopic submucosal dissection market is segmented by end-user into outpatient facilities and hospitals. Among these, the hospitals segment accounted for the largest share in 2024 and is expected to grow at a significant CAGR during the forecast period. Hospitals have state-of-the-art facilities and medical equipment, such as specialized instruments, imaging methods, and high-definition endoscopic systems. They provide a wide range of healthcare services, access to cutting-edge technologies, multidisciplinary care teams, collaborative care teams, inpatient monitoring facilities, and a nurturing environment for research and innovation, all of which improve the health of patients and segment expansion.

Competitive Analysis:

The report offers the appropriate analysis of the key organizations/companies involved within the US endoscopic submucosal dissection market, along with a comparative evaluation primarily based on their product offering, business overviews, geographic presence, enterprise strategies, segment market share, and SWOT analysis. The report also provides an elaborative analysis focusing on the current news and developments of the companies, which includes product development, innovations, joint ventures, partnerships, mergers & acquisitions, strategic alliances, and others. This allows for the evaluation of the overall competition within the market.

List of Key Companies

• FUJIFILM Holdings Corporation
• STERIS plc.
• Creo Medical
• Olympus Corporation
• Boston Scientific Corporation
• Karl Storz GmbH & Co. KG
• Medtronic
• Others

Recent Developments:

• In May 2025, EndoQuest Robotics completed two procedures using its endoluminal system, while Virtuoso Surgical successfully performed bladder lesion excision in six patients. The technology, designed to navigate through natural body openings, was approved for use in colorectal lesions procedures. The first two endoscopic submucosal dissections were performed on complex lesions in the rectum and sigmoid colon.

Key Target Audience

• Market Players
• Investors
• End-users
• Government Authorities 
• Consulting and Research Firm
• Venture capitalists
• Value-Added Resellers (VARs)

Market Segment

This study forecasts revenue at the United States, regional, and country levels from 2020 to 2035. Spherical Insights has segmented the US endoscopic submucosal dissection market based on the below-mentioned segments:

US Endoscopic Submucosal Dissection Market, By Product

• Injection Agents
• Gastroscopes & Colonoscopes
• Graspers
• Tissue Retractors
• Knives

US Endoscopic Submucosal Dissection Market, By Indication

• Colon Cancer
• Oesophageal Cancer
• Stomach Cancer

US Endoscopic Submucosal Dissection Market, By End-User

• Outpatient Facilities
• Hospitals