Global Collagen and Hyaluronic Acid Intra-Articular Injections Market Size, Share, and COVID-19 Impact Analysis, By Product Type (Hyaluronic Acid Injection, Collagen Injection, and Combination of Hyaluronic Acid & Collagen), By Application (Knee Osteoarthritis, Joint Pain, Veterinary Applications, Post-Operative Recovery, and Others), By Distribution Channel (Hospital Pharmacies, Retail Pharmacies, and Online Pharmacies), and By Region (North America, Europe, Asia-Pacific, Latin America, Middle East, and Africa), Analysis and Forecast 2025 - 2035

Global Collagen and Hyaluronic Acid Intra-Articular Injections Market Insights Forecasts to 2035

• The Global Collagen and Hyaluronic Acid Intra-Articular Injections Market Size Was Estimated at USD 3.01 Billion in 2024
• The Market Size is Expected to Grow at a CAGR of around 6.09% from 2025 to 2035
• The Worldwide Collagen and Hyaluronic Acid Intra-Articular Injections Market Size is Expected to Reach USD 5.77 Billion by 2035
• Asia Pacific is expected to grow the fastest during the forecast period.

The global collagen and hyaluronic acid intra-articular injections market size was worth around USD 3.01 billion in 2024 and is predicted to grow to around USD 5.77 billion by 2035 with a compound annual growth rate (CAGR) of 6.09% from 2025 to 2035. The growing prevalence of osteoarthritis and joint disorders, as well increasing aging population, are driving the global market demand for collagen and hyaluronic acid intra-articular injections.  

Market Overview

The collagen and hyaluronic acid intra-articular injections market is the industry related to medical products encompassing the injecting of collagen or hyaluronic acid (HA) directly into a joint, typically to treat osteoarthritis or other joint conditions. Collagen and hyaluronic acid IA injection provides pain reduction and aids in improving osteoarthritis. Osteoarthritis is a degenerative, progressive joint disease, with the hand, hip, and knee being the most affected joints. The growing prevalence of musculoskeletal disorders, including osteoarthritis and rheumatoid arthritis, and other joint-related ailments, and sports injuries is driving the demand for these injections for effective pain relief and improved mobility for patients. Further, the increasing need for non-invasive therapies is encouraging the potential application of intra-articular injections across medical and wellness sectors. An increasing need for minimally invasive treatment, with the growing technological advancements for improved efficacy and safety of these injections, is providing growth opportunities in the collagen and hyaluronic acid intra-articular injections market.

Report Coverage

This research report categorizes the collagen and hyaluronic acid intra-articular injections market based on various segments and regions, forecasts revenue growth, and analyzes trends in each submarket. The report analyses the key growth drivers, opportunities, and challenges influencing the collagen and hyaluronic acid intra-articular injections market. Recent market developments and competitive strategies such as expansion, type launch, development, partnership, merger, and acquisition have been included to draw the competitive landscape in the market. The report strategically identifies and profiles the key market players and analyses their core competencies in each sub-segment of the collagen and hyaluronic acid intra-articular injections market.

Driving Factors

The increasing burden of joint disorders, including rheumatoid arthritis and sports-related injuries, is anticipated to drive the market demand for collagen and hyaluronic acid intra-articular injections. The growing prevalence of osteoarthritis with an ageing population and increasing rates of obesity and injury is driving the need for therapy directed at reducing pain and improving function. An increasing demand for non-surgical, minimally invasive solutions, along with growing awareness among patients and physicians about early interventions and joint health treatments contributing to propelling the market.

Restraining Factors

The increased cost and availability of alternative treatments, including physical therapies and oral medication treatments, are hindering the market. Further, implementation of stringent regulations that can be time-consuming and costly may hamper the market growth. 

Market Segmentation

The collagen and hyaluronic acid intra-articular injections market share is classified into product type, application, and distribution channel.

• The hyaluronic acid injection segment dominated the market in 2024 and is projected to grow at the fastest CAGR during the forecast period.

Based on the product type, the collagen and hyaluronic acid intra-articular injections market is divided into hyaluronic acid injection, collagen injection, and combination of hyaluronic acid & collagen. Among these, the hyaluronic acid injection segment dominated the market in 2024 and is projected to grow at the fastest CAGR during the forecast period. Hyaluronic acid is directly delivered into the knee joints to restore synovial fluid viscosity and improve joint function. The adoption of hyaluronic acid injection as part of treatment protocols, along with its ease of accessibility, is driving the market in the hyaluronic acid injection segment.

• The knee osteoarthritis segment accounted for a significant share in 2024 and is anticipated to grow at the fastest CAGR during the forecast period.

Based on the application, the collagen and hyaluronic acid intra-articular injections market is divided into knee osteoarthritis, joint pain, veterinary applications, post-operative recovery, and others. Among these, the knee osteoarthritis segment accounted for a significant share in 2024 and is anticipated to grow at the fastest CAGR during the forecast period. Knee osteoarthritis is a degenerative joint disease of the knee, caused by wear and strain and gradual articular cartilage loss. The growing advancement in injection therapies, with the rising investment, is propelling the market growth in the knee osteoarthritis segment.

• The hospital pharmacies segment accounted for a significant share in 2024 and is anticipated to grow at the fastest CAGR during the forecast period.

Based on the distribution channel, the collagen and hyaluronic acid intra-articular injections market is divided into hospital pharmacies, retail pharmacies, and online pharmacies. Among these, the hospital pharmacies segment accounted for a significant share in 2024 and is anticipated to grow at the fastest CAGR during the forecast period. Hospital pharmacies are the primary source of post-operative osteoarthritis care, which is responsible for driving the sales volume of these intra-articular injections.

Regional Segment Analysis of the Collagen and Hyaluronic Acid Intra-Articular Injections Market

• North America (U.S., Canada, Mexico) 
• Europe (Germany, France, U.K., Italy, Spain, Rest of Europe)
• Asia-Pacific (China, Japan, India, Rest of APAC)
• South America (Brazil and the Rest of South America) 
• The Middle East and Africa (UAE, South Africa, Rest of MEA)

North America is anticipated to hold the largest share of the collagen and hyaluronic acid intra-articular injections market over the predicted timeframe.u83yu

North America is anticipated to hold the largest share of the collagen and hyaluronic acid intra-articular injections market over the predicted timeframe. The adoption of advanced medical treatments, along with heightened awareness about non-surgical therapeutic options, is promoting the collagen and hyaluronic acid intra-articular injections market. Further, the increased rate of osteoarthritis in the region, as well as robust reimbursement regulations and usage of minimally invasive procedures, are propelling the market.

Asia Pacific is expected to grow at a rapid CAGR in the collagen and hyaluronic acid intra-articular injections market during the forecast period. An increasing awareness about joint health treatments, with increased accessibility to healthcare services, especially in emerging economies like China, India, and Southeast Asian countries, aids in propelling the market growth. Further, the surging medical tourism in the region that drives the demand for technologically advanced medical proficiencies is contributing to driving the market growth.

Competitive Analysis:

The report offers the appropriate analysis of the key organizations/companies involved within the collagen and hyaluronic acid intra-articular injections market, along with a comparative evaluation primarily based on their type of offering, business overviews, geographic presence, enterprise strategies, segment market share, and SWOT analysis. The report also provides an elaborative analysis focusing on the current news and developments of the companies, which includes type development, innovations, joint ventures, partnerships, mergers & acquisitions, strategic alliances, and others. This allows for the evaluation of the overall competition within the market.

List of Key Companies

• Seikagaku Corporation
• Bioventus, Inc.
• Anika Therapeutics, Inc.
• Zimmer Biomet
• Sanofi
• Teva Pharmaceutical Industries Ltd.
• Ferring B.V.
• Reddy's Laboratories Ltd.
• Fidia Farmaceutici S.p.A.
• Semical Biosurgery
• Avanos Medical, Inc.
• Maxigen Biotech Inc. (MBI)
• Others

Key Target Audience

• Market Players
• Investors
• End-users
• Government Authorities 
• Consulting And Research Firm
• Venture capitalists
• Value-Added Resellers (VARs) 

Recent Development

• In February 2024, MBI announced that ArtiAid and ArtiAidPlus Intra-articular Injection have received marketing authorization from the Saudi Food and Drug Authority.

Market Segment

This study forecasts revenue at global, regional, and country levels from 2020 to 2035. Spherical Insights has segmented the collagen and hyaluronic acid intra-articular injections market based on the below-mentioned segments: 

Global Collagen and Hyaluronic Acid Intra-Articular Injections Market, By Product Type

• Hyaluronic Acid Injection
• Collagen Injection
• Combination of Hyaluronic Acid & Collagen

Global Collagen and Hyaluronic Acid Intra-Articular Injections Market, By Application

• Knee Osteoarthritis
• Joint Pain
• Veterinary Applications
• Post-Operative Recovery
• Others

Global Collagen and Hyaluronic Acid Intra-Articular Injections Market, By Distribution Channel

• Hospital Pharmacies
• Retail Pharmacies
• Online Pharmacies

Global Collagen and Hyaluronic Acid Intra-Articular Injections Market, By Regional Analysis

• North America
  • US
  • Canada
  • Mexico
• Europe
  • Germany
  • UK
  • France
  • Italy
  • Spain
  • Russia
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Australia
  • Rest of Asia Pacific
• South America
  • Brazil
  • Argentina
  • Rest of South America
• Middle East & Africa
  • UAE
  • Saudi Arabia
  • Qatar
  • South Africa
  • Rest of the Middle East & Africa