Global Hypothermic Machine Perfusion Market Size To Exceed USD 6739.5 Million By 2035

Global Hypothermic Machine Perfusion Market Size To Exceed USD 6739.5 Million By 2035

According to a research report published by Spherical Insights & Consulting, The Global Hypothermic Machine Perfusion Market Size is Expected To Grow from USD 3185.0 Million in 2024 to USD 6739.5 Million by 2035, at a CAGR of 7.05% during the forecast period 2025-2035.

Browse 210 Market Data Tables And 45 Figures Spread Through 190 Pages and In-Depth TOC On the "Global Hypothermic Machine Perfusion Market Size, Share, and COVID-19 Impact Analysis, By Organ Type (Heart, Lung, Kidney, Liver, Pancreas, and Composite Tissue (VCA)), By End User (Transplant Centers, Hospitals, and Academic & Research Institutes), and By Region (North America, Europe, Asia-Pacific, Latin America, Middle East, and Africa), Analysis and Forecast 2025 – 2035. " Get Detailed Report Description Here:https://www.sphericalinsights.com/reports/hypothermic-machine-perfusion-market

The Hypothermic Machine Perfusion Market Size is an industry focusing on providing technology and devices for preserving donor organs using a cold, oxygenated solution. Hypothermic machine perfusion is an alternative to static cold storage for preserving organs for transplantation, utilising a machine to pump a cold solution through the organ. It is considered as National standard preservation method for deceased donor kidneys. Increasing improvements in healthcare accessibility, along with favorable government initiatives, are escalating the market opportunity for hypothermic machine perfusion. The increasing number of organ transplants, which is estimated to be more than 144,000, is primarily propelling the hypothermic machine perfusion market. Further, the support of funding and healthcare expenditure, which affect the progress of organ transplantation in terms of quantity and quality, is driving the market. On the contrary, the increased cost of organ transplantation, ethical concerns, and scarcity of trained professionals are challenging the market.  

The kidney segment dominated the market with a major share of about 41.5% in 2024 and is projected to grow at a substantial CAGR during the forecast period.

Based on the organ type, the hypothermic machine perfusion market size is divided into heart, lung, kidney, liver, pancreas, and composite tissue (VCA). Among these, the kidney segment dominated the market with a major share of about 41.5% in 2024 and is projected to grow at a substantial CAGR during the forecast period. Kidney transplantation refers to the treatment of choice for patients with end-stage renal disease (ESRD), as it has better outcomes compared to dialysis. For instance, in October 2022, Organ Recovery Systems’ LifePort kidney transporter awarded an exclusive contract for kidney transplant preservation services in Belgium.

The transplant centers segment accounted for the largest revenue share of about 55.1% in 2024 and is anticipated to grow at a remarkable CAGR during the forecast period.

Based on the end user, the hypothermic machine perfusion market is divided into transplant centers, hospitals, and academic & research institutes. Among these, the transplant centers segment accounted for the largest revenue share of about 55.1% in 2024 and is anticipated to grow at a remarkable CAGR during the forecast period. The presence of specialized trained staff and donor coordination mandates in the transplant centres is responsible for driving the segmental market. In October 2025, the Transplant Center at Mayo Clinic in Florida performed its 10,000th transplant, which represents a reflection of the lives transformed through the gift of organ donation.

North America is expected to hold the majority share of the global hypothermic machine perfusion market during the forecast period.

North America is expected to hold the majority share of over 39.5% in the global hypothermic machine perfusion market during the forecast period. The U.S. is the dominating country in the North America hypothermic machine perfusion market with the largest share of approximately 39.1%, driven by the growing number of organ transplants, along with an increasing number of approvals of products utilized for kidney preservation and transplantation. The market ecosystem in North America is strong, due to an increasing adoption of cutting-edge organ preservation solutions, with the integration of sensors and AI-driven analytics for monitoring precise organ viability. The market for hypothermic machine perfusion has been driven by the region's supportive regulatory frameworks, along with the presence of robust healthcare infrastructure and increased transplantation rates.

Asia Pacific is anticipated to grow at the fastest pace of CAGR 6.8% in the global hypothermic machine perfusion market during the forecast period. Japan is leading the Asia Pacific hypothermic machine perfusion market, owing to the integration of AI-driven predictive analytics and machine learning into organ preservation practices in the healthcare sector. The Asia Pacific area has a thriving market for hypothermic machine perfusion due to its increasing awareness about organ donation, along with the increasing government initiatives for supporting organ transplantation with favourable policies.

Major vendors in the global hypothermic machine perfusion market are Organ Recovery Systems, XVIVO, IGL, Bridge to Life Ltd, Vascular Perfusion Solutions, Inc., Paragonix Technologies, TransMedics, Getinge AB, Medtronic, LivaNova PLC, Terumo Corporation, and Others.

Key Target Audience

• Market Players
• Investors
• End-users
• Government Authorities 
• Consulting and Research Firm
• Venture capitalists
• Value-Added Resellers (VARs)

Key Market Development 

• In November 2025, Organ Recovery Systems (ORS), a global leading provider of organ perfusion devices and services, announced that the New England Journal of Medicine (NEJM) published detailed, 10-year follow-up data from a 2009 Mowers et al. landmark clinical study.  

• In September 2025, the first-ever multicenter study of Hypothermic Oxygenated Perfusion (HOPE) in pediatric liver transplantation using any machine perfusion devices was presented at the 13^th Congress of the International Pediatric Transplant Association (IPTA) in Berlin, Germany.

• In January 2025, Paragonix Technologies, a pioneer in organ transplant technologies and organ procurement services, announced the completion of the world’s first in-human cases utilizing its FDA-cleared KidneyVault Portable Renal Perfusion System, marking a new chapter in kidney transplant preservation.

Market Segment

This study forecasts revenue at global, regional, and country levels from 2020 to 2035. Spherical Insights has segmented the hypothermic machine perfusion market based on the below-mentioned segments:

Global Hypothermic Machine Perfusion Market, By Organ Type

• Heart
• Lung
• Kidney
• Liver
• Pancreas
• Composite Tissue (VCA)

Global Hypothermic Machine Perfusion Market, By End User

• Transplant Centers
• Hospitals
• Academic & Research Institutes

 Global Hypothermic Machine Perfusion Market, By Regional Analysis

• North America
  • US
  • Canada
  • Mexico
• Europe
  • Germany
  • UK
  • France
  • Italy
  • Spain
  • Russia
  • Rest of Europe
• Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Australia
  • Rest of Asia Pacific
• South America
  • Brazil
  • Argentina
  • Rest of South America
• Middle East & Africa
  • UAE
  • Saudi Arabia
  • Qatar
  • South Africa
  • Rest of the Middle East & Africa

About the Spherical Insights & Consulting

Spherical Insights & Consulting is a market research and consulting firm which provides actionable market research study, quantitative forecasting and trends analysis provides forward-looking insight especially designed for decision makers and aids ROI.

Which is catering to different industry such as financial sectors, industrial sectors, government organizations, universities, non-profits and corporations. The company's mission is to work with businesses to achieve business objectives and maintain strategic improvements. 

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